專長與研究領域

• 環境及奈米毒理學
• 癌症合併放射及化療醫學
• 化學致癌及癌症化學預防
• 細胞自體吞噬研究

開授課程

• 環境毒理學
• 進階毒理學
• 實驗毒理學
• 化學癌瘤
• 儀器分析

學歷

• 台灣大學生化學暨分子生物學研究所博士

經歷

• 成功大學工業衛生學科暨環境醫學研究所特聘教授(2017~)
• 成功大學工業衛生學科暨環境醫學研究所所長(2015~2018)
• 成功大學工業衛生學科暨環境醫學研究所教授(2009~2017)
• 成功大學工業衛生學科暨環境醫學研究所副教授(2003~2009)
• 成功大學工業衛生學科暨環境醫學研究所助理教授(1998~2003)
• 台灣大學醫學院附設醫院 博士後研究     (1997-1998)
• 台灣大學醫學院生化所 博士後研究       (1995-1997)
• 國際醫學地質學會(IMGA)臺灣分會秘書長
• 台灣毒物學會理事(2018~2022)
• 亞洲毒理學會秘書長(2021~)
• 國科會生物處公共衛生與環境醫學學門計畫審查覆審委員(2010)
• PLoS ONE Academic editor 2014, 2015
• Journal of Life Sciences (ISSN1934-7391), USA 科學雜誌之編輯群(Editorial Board) (2010)

著作

期刊論文

1. B-J Wang, Y-Y Chen, H-H Chang, R-J Chen, Y-J Wang*, Y-H Lee*. Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury. Part Fibre Toxicol. 2024 Feb 28;21(1):9. (SCI IF=10.0 Rank: 9/94=4.25% in Toxicology, JCR2022) (Corresponding author)
2. Y-H Wu, R-J Chen, H-W Chiu, L-X Yang, Y-L Wang, Y-Y Chen, Y-L Yeh, M-Y Liao* and Y-J Wang*. Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy. Theranostics. 2023, 13(1):40-58. (SCI IF=11.6 rank: 13/139=9.35% in Medicine, esearch & Experimental, JCR 2021) (Corresponding author)
3. Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, Y-H Lee* and Y- J Wang*. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. Ecotoxicol Environ Saf. 2022, 243:113967. (SCI IF=7.129 rank: 7/94=7.45 % in Toxicology, JCR 2021) (Corresponding author)
4. Y-H Wu, S-Y Ho, B-J Wang* and Y- J Wang*. Mechanisms of Nanotoxicology and the Important Role of Alternative Testing Strategies. Int J Mol Sci. 2022, 23(15):8204. (SCI IF=6.208 Rank: 69/297=23.23% in Biochemistry & Molecular Biology, JCR 2021) (Corresponding author)
5. C-C Huang*, T-H Chen, C-H Ho, Y-C Chen, R-J Chen, Y-J Wang, C-C Hsu, H-J Lin, J-J Wang, C-P Chang, H-R Guo*. Risks of Developing Diabetes and Hyperglycemic Crisis Following Carbon Monoxide Poisoning: A Study Incorporating Epidemiologic Analysis and Animal Experiment. Clin Epidemiol. 2022, 14:1265-1279. (SCI IF=5.814 Rank: 46/210=21.9% in Public, Environmental and Occupational Health, JCR 2021)
6. B-H Mao, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee, S-J Yan* and Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 19(1):6 (2022) (SCI IF= 9.4 rank: 3/93=3.22 % in Toxicology, JCR 2020) (Corresponding author)
7. Y-Y Chen, Y-H Lee, B-J Wang, R-J Chen* and Y-J Wang*. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 19(1):2 (2022) (SCI IF= 9.4 rank: 3/93=3.22 % in Toxicology, JCR 2020) (Corresponding author)
8. Z-Y Chen, Y-C Su, F-Y Cheng, S-J Yan* and Y-J Wang*. Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene. Environ. Sci.: Nano, 8:3774-3791 (2021) (SCI IF=8.131. Rank: 22/274=8.02% in Environmental Science, JCR 2020) (Corresponding author)
9. R-J Chen, Y-J Lyu, Y-Y Chen, Y-C Lee, M-H Pan, Y-S Ho* and Y-J Wang*. Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. Molecules. 26(21):6741 (2021) (SCI IF=4.412. Rank: 115/297=38.72% in Biochemistry & molecular biology, JCR 2020) (Corresponding author)
10. R-J Chen, C-C Huang, Rosita Pranata, Y-H Lee, Y-Y Chen, Y-H Wu*, Y-J Wang*. Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. Int J Mol Sci. 2021, In press. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
11. F-Y Cheng, C-H Chan, B-J Wang, Y-L Yeh, Y-J Wang* and H-W Chiu* The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer. Cancers (Basel). In press. (SCI IF=6.126 Rank: 37/244=15.16% in Oncology, JCR 2019) (Corresponding author)
12. R-J Chen, Y-H Lee, T-H Chen, Y-Y Chen, Y-L Yeh, C-P Chang, Cn-Cg Huang, H-R Guo*, Ying-Jan Wang*. Carbon monoxide-triggered health effects: The important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Arch. Toxicology. In Press. (SCI IF=5.059 Rank: Q1 in Toxicology, JCR 2019) (Corresponding author)
13. Y-J Wang, Y-Y Chen, C-M Hsiao, M-H Pan, B-J Wang, Y-C Chen, C-T Ho, K-C Huang and R-J Chen*. Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition. Front Cell Dev Biol. 2020; 8: 436. (SCI IF=5.201 Rank: 6/41=14.63% in Developmental biology, JCR 2019) (First author)
14. Y-H Wu, S-Y Ho, B-J Wang* and Y-J Wang*. The Recent Progress in Nanotoxicology and Nanosafety from the Point of View of Both Toxicology and Ecotoxicology. Int J Mol Sci. 2020, 21(12): 4209. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
15. R-J Chen,Y-Y Chen, M-Y Liao, Y-H Lee, Z-Y Chen, S-J Yan, Y-L Yeh, L-X Yang, Y-L Lee, Y-H Wu*, Y-J Wang*. The current understanding of autophagy in nanomaterial toxicity and its implementation in safety assessment-related alternative testing strategies. Int J Mol Sci. 2020, 30;21(7):2387. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
16. Z-Y Chen, N-J Li, F-Y Cheng, J-F Hsueh, C-C Huang, F-I Lu, T-F Fu, S-J Yan, Y-H Lee* and Y-J Wang*. The effect of the chorion on size-dependent developmental toxicity and underlying mechanisms of amine-modified silver nanoparticles in zebrafish embryos. Int J Mol Sci. 2020, accepted. (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
17. S-Y Ho, W-S Wu, L-C Lin, Y-H Wu, H-W Chiu, Y-L Yeh, B-M Huang*, Y-J Wang*. Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest. Int J Mol Sci. 2019 Oct, 20(21). pii: E5366. (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
18. Y-H Lee, Y-Y Chen, Y-L Yeh, Y-J Wang* and R-J Chen*. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. Int J Mol Sci. 2019, 20(11): pii: E2716. (SCI IF=4.183 rank: 46/172=26.74% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
19. B-J Wang, H-W Chiu, Y-Lin Lee, C-Yi Li, Y-J Wang* and Y-H Lee*. Pterostilbene attenuates hexavalent chromium-induced allergic contact dermatitis by preventing cell apoptosis and inhibiting IL-1β-related NLRP3 inflammasome activation. Journal of Clinical Medicine. 2018, 7(12):489 (SCI IF=5.688 rank: 15/160=9.38% in Medicine, General & Internal, JCR 2018) (Corresponding author)
20. Y-H Wu; W-S Wu; L-C Lin; C-S Liu; S-Y Ho; B-J Wang; B-M Huang; Y-L Yeh; H-W Chiu; W-L Yang*; Y-J Wang*. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation. J Exp Clin Canc Res. 2018, 37;91 (SCI IF=5.646 rank: 40/229=17.47% in Oncology, JCR 2018) (Corresponding author)
21. Mao B-H, Chen Z-Y, Wang Y-J*, Yan S-J*. Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Sci Rep. 2018 Feb 5;8(1):2445. (SCI IF=4.011 rank: 15/69 =21.74% in Multidisciplinary sciences, JCR 2018) (Corresponding author)
22. Chen R-J, Kuo H-C, Cheng L-H, Lee Y-H, Chang W-T, Wang B-J, Wang Y-J*, Cheng H-C*. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer. Int J Mol Sci. 2018 Jan 18;19(1). (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
23. Wu J-C, Tsai M-L, Lai C-S, Lo C-Y, Ho C-T, Wang Y-J*, Pan M-H*. Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism and ameliorate autophagic defect in ICR mice. Int J Cancer. 2018 Apr 15;142(8):1689-1701. (SCI IF=4.982 rank: 51/229=22.27% in Oncology, JCR 2018) (Corresponding author)

研討會論文

1. Tzu-Ning Li, Zi-Yu Chen, Ying-Jan Wang. Exploring the Predictability of Tiered Alternative tests in Fish Acute Toxicity. The 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12). Niagara Falls, Canada. (Virtual Conference) Aug 27-31, 2023.
2. Tzu-Hao Chen, Chien-Cheng Huang, Ying-Jan Wang, How-Ran Guo, Ching-Ping Chang. Peripheral immune alterations after carbon monoxide poisoning are associated with gut microbiota changes and the corresponding metabolites. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
3. Yung-Hsuan Cheng, Bour-Jr Wang, Ying-Jan Wang. Pterostilbene prevents chlorothalonil induced allergic contact dermatitis: The interaction of oxidative stress and infl ammasome activation. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
4. Jui-Chun Kuo, Ying-Jan Wang. Using New Approach Methodologies (NAMs) to Establish Nonpolar Narcosis Substance in Integrated Testing Strategy (ITS) for Ecotoxicity. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
5. Jing-Yu Lu, Ying-Jan Wang. Establishment of a high-throughput nanotoxicity testing model using autophagy in zebrafish. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
6. Tzu-Ning Li, Zi-Yu Chen, Ying-Jan Wang. Exploring the predictability of tiered alternative tests in fish acute toxicity. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
7. Yen-Ling Lee, Zi-Yu Chen, Jian-feng Hsueh, Ying-Jan Wang. A novel integrated testing strategy (ITS) for evaluating acute fish toxicity with zebrafish and OECD QSAR Toolbox. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
8. Hui-Hsuan Chang, Guan-Yu Huang, Ying-Jan Wang and Yu-Hsuan Lee. The role of autophagy in zinc oxide nanoparticle–induced skin damage under UVB irradiation. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
9. Hsuan-I Wu, Bour-Jr Wang, Ying-Jan Wang. Repeated exposure of chlorothalonil combine with UVR induced skin aging through the interplay of NLRP3 inflammasome and autophagy. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
10. Yuan-Hua Wu, Chia-Yi Chen, Ying-Jan Wang. Cisplatin-Loaded Nanomedicine Enhances Radiosensitivity by Inducing Ferroptosis and Autophagy Dysfunction via Impairment of Lysosomes in Triple-Negative Breast Cancer. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
11. Sheng-Yow Ho, Yi-Jing Chen, Mei-Yi Liao, Ying-Jan Wang. Carbon Monoxide (CO) Nano-drug Delivery System for Cancer Radiodynamic Therapy via Affecting Mitochondrial Function. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
12. Kuo-Ching Huang, Rosita Pranata, Yu-Ting Chang, Yen-Lin Chen, Ying-Jan Wang, and Rong-Jane Chen. Chondroitin sulfate oligosaccharide ameliorates osteoarthritis via NLRP3 inflammasome inactivation. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023.
13. Ying-Jan Wang. The Possible Role of Autophagy in Nanomaterials Safety Assessment-Related Alternative Testing Strategies: Take the Ag/ZnO NPs for example. The 10th International Congress of Asian Society of Toxicology (ASIATOX-X). Taipei, Taiwan. Jul 17-20, 2023. (Invited speaker)
14. Ying-Jan Wang. The Possible Role of Autophagy in Nanomaterials Safety Assessment-Related Alternative Testing Strategies: Take the Ag/ZnO NPs for example. 2023 International Symposium of Precision Environmental Medicine (ISPEM): Clinical and Translational Research. Kaohsiung, Taiwan. Apr 29, 2023. (Keynote speaker)
15. 中國毒理學會第十次全國毒理學大會。Zhuhai, China. Apr 8-11, 2023.
16. Ying-Jan Wang. ZnONPs combined with UVR-induced cellular senescence through the interplay among mitochondria, genotoxicity and exosome-autophagy axis. The 37th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 18-19, 2023.
17. Jing-Yu Lu, Ying-Jan Wang. Establishment of a high-throughput nanotoxicity testing model using autophagy in zebrafish. The 37th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 18-19, 2023.
18. Jui-Chun Kuo, Ying-Jan Wang. Using New Approach Methodologies (NAMs) to Establish Nonpolar Narcosis Substance in Integrated Testing strategy (ITS) for Ecotoxicity. The 37th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 18-19, 2023.
19. Chia-Yi Chen, Ya-Ling Yeh, Ying-Jan Wang. Cisplatin-Loaded Nanomedicine Enhances Radiosensitivity by Inducing Ferroptosis and Autophagy Dysfunction via Impairment of Lysosomes in Triple-Negative Breast Cancer. The 37th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 18-19, 2023.
20. Tzu-Hao Chen, Ching-Ping Chang, Chien-Cheng Huang, Ying-Jan Wang. Hyperbaric oxygen therapy attenuates the pulmonary immune-inflammatory response and diminishes pyroptosis after carbon monoxide poisoning. The 37th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 18-19, 2023.
21. Tzu-Ning Li, Zi-Yu Chen, Ying-Jan Wang. Exploring the Predictability of Tiered Alternative tests in Fish Acute Toxicity. 2022 Taiwan Zebrafish Symposium. Taichung, Taiwan. Dec 3, 2022.
22. Tzu-Ning Li, Zi-Yu Chen, Ying-Jan Wang. Exploring the Predictability of Tiered Alternative tests in Fish Acute Toxicity. 2022年第三屆生態毒理研討會。Pingtung, Taiwan. Sep 23, 2022.
23. Tzu-Ning Li, Ying-Jan Wang. Exploring the Predictability of Mode of Action Combined with Tiered Alternative Tests in Fish Acute Toxicity. The 36th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 25-27, 2022.
24. Hsuan-I Wu, Ying-Jan Wang. Long-term Exposure of Chlorothalonil and Photodegradation Product Induced Skin Aging Through Inect of Pterostilbene. The 36th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 25-27, 2022.
25. Chia-Yi Chen, Ya-Ling Yeh, Ying-Jan Wang. Fucoidan-Based Nanomedicine for Overcoming Cisplatin Resistance by Decreasing EMT and Inducing Autophagic Cell Death Enhances Radiosensitivity in Triple-Negative Breast Cancer. The 36th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 25-27, 2022.
26. Sih-Shan Chen, Yi-Ping Lee, Ying-Jan Wang, Bu-Miin Huang. Cordycepin enhances radiosensitivity to induce apoptosis and/or autophagy in mouse Leydig cell lines through ROS production. The 36th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 25-27, 2022.
27. Ying-Jan Wang. The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies: Take the Ag/ZnO NPs for example. The 36th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 25-27, 2022. (Oral presentation)
28. Yu-Ying Chen, Rong-Jane Chen, Ying-Jan Wang. Pterostilbene Protects UVB Combined with ZnO Nanoparticles-Induced Skin Damage through Downregulation of Inflammasome Activation. 2022 臺灣粒線體醫學暨研究學會學術研討會暨年會。Kaohsiung, Taiwan. Mar 19, 2022.
29. 王應然。OECD脊椎動物生態毒理替代測試：法規的適用性及科學的合理性評估。挑戰與地圖—推動台灣動物實驗3Rs替代，推動台灣動物實驗替代研討會。Taipei, Taiwan. (Virtual Conference) Nov 20-21, 2021. (Keynote speaker)
30. Ying-Jan Wang. Autophagy could be an early biomarker of nanotoxicity in safety assessment-related alternative testing strategies: Take the silver nanoparticle for example. The 3rd IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability (ECBIOS). Tainan, Taiwan. May 29, 2021. (Keynote speaker)
31. Chiao-Ching Huang and Ying-Jan Wang. Effects of silver nanoparticles on innate immunity in zebrafish and the protective effect of pterostilbene. NANOTEXNOLOGY 2020: International Conferences & Exhibition on Nanotechnologies - Organic Electronics & Nanomedicine. Thessaloniki, Greece. Jul 4-11, 2020.
32. Ying-Jan Wang, Shih-Yi Hun, Yu-Hsuan Lee and Hui-Wen Chiu. ER stress triggered autophagy may contribute to the enhanced immune response of nanoparticles in an allergic contact dermatitis animal model induced by chromium (VI). 5th International Earth Science, Geology, Oil and Gas Conference. Kuala Lumpur, Malaysia. Dec 2-3, 2019. (Keynote speaker)
33. Ying-Jan Wang. Toxic effects of Silver nanoparticle with regard to hazard identification and safety evaluation. 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications, Columbus, OH, USA. July 29-31, 2019. (Invited speaker)
34. Chiao-Ching Huang, Yu-Hsuan Lee, Ying-Jan Wang. The Toxicological Effects of Silver Nanoparticles on Immune System in Zebrafish Model and the Protective Effect of Natural Compound. The 34th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 23-24, 2019.
35. Yung-Hsuan Cheng, Yu-Hsuan Lee, Ying-Jan Wang. Study of Alleviating Pesticide-induced Allergic Contact Dermatitis Via Inhibit ROS And Inflammasome Activation. The 34th Joint Annual conference of Biomedical Science. Taipei, Taiwan. Mar 23-24, 2019.

專書

1. Ying-Jan Wang. Prevention of Occupational and Environmental Exposures, in: A. Murat Tuncer (ed.): Cancer Report of Asian-Pacific Region . 2010.
2. 郭育良、王應然、許昺奇、郭浩然、蔡朋枝、蘇德勝、王士旻、黃奕孝（2012年07月）。職業與疾病。華杏出版股份有限公司。
3. Wang Y-J and Chen R-J. CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, Ch27 Pterostilbene Protection and Bladder Cancer Cells. First edition 2014, Copyright © 2014 Elsevier Inc.
4. Ying-JanWang. Nanotoxicology and Nanosafety 2.0 International Journal of Molecular Sciences, 2020.