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王應然

 

王應然

特聘教授

台灣大學生化學暨分子生物學研究所博士

電話： +886-6-235-3535 ext.5804

Email：yjwang@mail.ncku.edu.tw

Research NCKU

專長與研究領域

  • 環境及奈米毒理學
  • 癌症合併放射及化療醫學
  • 化學致癌及癌症化學預防
  • 細胞自體吞噬研究

開授課程

  • 環境毒理學
  • 進階毒理學
  • 實驗毒理學
  • 化學癌瘤
  • 儀器分析

學歷

  • 台灣大學生化學暨分子生物學研究所博士

經歷

  • 成功大學工業衛生學科暨環境醫學研究所所長(2015~2018)
  • 成功大學工業衛生學科暨環境醫學研究所特聘教授(2017~)
  • 成功大學工業衛生學科暨環境醫學研究所教授(2009~2017)
  • 成功大學工業衛生學科暨環境醫學研究所副教授(2003~2009)
  • 成功大學工業衛生學科暨環境醫學研究所助理教授(1998~2003)
  • 台灣大學醫學院附設醫院 博士後研究     (1997-1998)
  • 台灣大學醫學院生化所 博士後研究       (1995-1997)
  • 國際醫學地質學會(IMGA)臺灣分會秘書長
  • 台灣毒物學會理事(2018~2022)
  • 亞洲毒理學會秘書長(2021~)
  • 國科會生物處公共衛生與環境醫學學門計畫審查覆審委員(2010)
  • PLoS ONE Academic editor 2014, 2015
  • Journal of Life Sciences (ISSN1934-7391), USA 科學雜誌之編輯群(Editorial Board) (2010)

著作

 

期刊論文

  1. Y-H Wu, R-J Chen, H-W Chiu, L-X Yang, Y-L Wang, Y-Y Chen, Y-L Yeh, M-Y Liao* and Y-J Wang*. Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy. Theranostics. 2023, 13(1):40-58. (SCI IF=11.6 rank: 13/139=9.35% in Medicine, esearch & Experimental, JCR 2021) (Corresponding author)
  2. Z-Y Chen, Y-C Yang, B-J Wang, F-Y Cheng, Y-L Lee, Y-H Lee* and Y- J Wang*. Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae. Ecotoxicol Environ Saf. 2022, 243:113967. (SCI IF=7.129 rank: 7/94=7.45 % in Toxicology, JCR 2021) (Corresponding author)
  3. Y-H Wu, S-Y Ho, B-J Wang* and Y- J Wang*. Mechanisms of Nanotoxicology and the Important Role of Alternative Testing Strategies. Int J Mol Sci. 2022, 23(15):8204. (SCI IF=6.208 Rank: 69/297=23.23% in Biochemistry & Molecular Biology, JCR 2021) (Corresponding author)
  4. C-C Huang*, T-H Chen, C-H Ho, Y-C Chen, R-J Chen, Y-J Wang, C-C Hsu, H-J Lin, J-J Wang, C-P Chang, H-R Guo*. Risks of Developing Diabetes and Hyperglycemic Crisis Following Carbon Monoxide Poisoning: A Study Incorporating Epidemiologic Analysis and Animal Experiment. Clin Epidemiol. 2022, 14:1265-1279. (SCI IF=5.814 Rank: 46/210=21.9% in Public, Environmental and Occupational Health, JCR 2021)
  5. B-H Mao, Y-K Luo, B-J Wang, C-W Chen, F-Y Cheng, Y-H Lee, S-J Yan* and Y-J Wang*. Use of an In silico Knowledge Discovery Approach to Determine Mechanistic Studies of Silver Nanoparticles-induced Toxicity from In vitro to In vivo. Particle and Fibre Toxicology. 19(1):6 (2022) (SCI IF= 9.4 rank: 3/93=3.22 % in Toxicology, JCR 2020) (Corresponding author)
  6. Y-Y Chen, Y-H Lee, B-J Wang, R-J Chen* and Y-J Wang*. Skin Damage Induced by Zinc Oxide Nanoparticles Combined with UVB is Mediated by Activating Cell Pyroptosis via the NLRP3 Inflammasome-Autophagy-Exosomal Pathway. Particle and Fibre Toxicology. 19(1):2 (2022) (SCI IF= 9.4 rank: 3/93=3.22 % in Toxicology, JCR 2020) (Corresponding author)
  7. Z-Y Chen, Y-C Su, F-Y Cheng, S-J Yan* and Y-J Wang*. Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene. Environ. Sci.: Nano, 8:3774-3791 (2021) (SCI IF=8.131. Rank: 22/274=8.02% in Environmental Science, JCR 2020) (Corresponding author)
  8. R-J Chen, Y-J Lyu, Y-Y Chen, Y-C Lee, M-H Pan, Y-S Ho* and Y-J Wang*. Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. Molecules. 26(21):6741 (2021) (SCI IF=4.412. Rank: 115/297=38.72% in Biochemistry & molecular biology, JCR 2020) (Corresponding author)
  9. R-J Chen, C-C Huang, Rosita Pranata, Y-H Lee, Y-Y Chen, Y-H Wu*, Y-J Wang*. Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. Int J Mol Sci. 2021, In press. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
  10. F-Y Cheng, C-H Chan, B-J Wang, Y-L Yeh, Y-J Wang* and H-W Chiu* The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer. Cancers (Basel). In press. (SCI IF=6.126 Rank: 37/244=15.16% in Oncology, JCR 2019) (Corresponding author)
  11. R-J Chen, Y-H Lee, T-H Chen, Y-Y Chen, Y-L Yeh, C-P Chang, Cn-Cg Huang, H-R Guo*, Ying-Jan Wang*. Carbon monoxide-triggered health effects: The important role of the inflammasome and its possible crosstalk with autophagy and exosomes. Arch. Toxicology. In Press. (SCI IF=5.059 Rank: Q1 in Toxicology, JCR 2019) (Corresponding author)
  12. Y-J Wang, Y-Y Chen, C-M Hsiao, M-H Pan, B-J Wang, Y-C Chen, C-T Ho, K-C Huang and R-J Chen*. Induction of Autophagy by Pterostilbene Contributes to the Prevention of Renal Fibrosis via Attenuating NLRP3 Inflammasome Activation and Epithelial-Mesenchymal Transition. Front Cell Dev Biol. 2020; 8: 436. (SCI IF=5.201 Rank: 6/41=14.63% in Developmental biology, JCR 2019) (First author)
  13. Y-H Wu, S-Y Ho, B-J Wang* and Y-J Wang*. The Recent Progress in Nanotoxicology and Nanosafety from the Point of View of Both Toxicology and Ecotoxicology. Int J Mol Sci. 2020, 21(12): 4209. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
  14. R-J Chen,Y-Y Chen, M-Y Liao, Y-H Lee, Z-Y Chen, S-J Yan, Y-L Yeh, L-X Yang, Y-L Lee, Y-H Wu*, Y-J Wang*. The current understanding of autophagy in nanomaterial toxicity and its implementation in safety assessment-related alternative testing strategies. Int J Mol Sci. 2020, 30;21(7):2387. (SCI IF=4.556 Rank: 74/297=24.92% in Biochemistry & molecular biology, JCR 2019) (Corresponding author)
  15. Z-Y Chen, N-J Li, F-Y Cheng, J-F Hsueh, C-C Huang, F-I Lu, T-F Fu, S-J Yan, Y-H Lee* and Y-J Wang*. The effect of the chorion on size-dependent developmental toxicity and underlying mechanisms of amine-modified silver nanoparticles in zebrafish embryos. Int J Mol Sci. 2020, accepted. (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
  16. S-Y Ho, W-S Wu, L-C Lin, Y-H Wu, H-W Chiu, Y-L Yeh, B-M Huang*, Y-J Wang*. Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest. Int J Mol Sci. 2019 Oct, 20(21). pii: E5366. (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
  17. Y-H Lee, Y-Y Chen, Y-L Yeh, Y-J Wang* and R-J Chen*. Stilbene Compounds Inhibit Tumor Growth by the Induction of Cellular Senescence and the Inhibition of Telomerase Activity. Int J Mol Sci. 2019, 20(11): pii: E2716. (SCI IF=4.183 rank: 46/172=26.74% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
  18. B-J Wang, H-W Chiu, Y-Lin Lee, C-Yi Li, Y-J Wang* and Y-H Lee*. Pterostilbene attenuates hexavalent chromium-induced allergic contact dermatitis by preventing cell apoptosis and inhibiting IL-1β-related NLRP3 inflammasome activation. Journal of Clinical Medicine. 2018, 7(12):489 (SCI IF=5.688 rank: 15/160=9.38% in Medicine, General & Internal, JCR 2018) (Corresponding author)
  19. Y-H Wu; W-S Wu; L-C Lin; C-S Liu; S-Y Ho; B-J Wang; B-M Huang; Y-L Yeh; H-W Chiu; W-L Yang*; Y-J Wang*. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation. J Exp Clin Canc Res. 2018, 37;91 (SCI IF=5.646 rank: 40/229=17.47% in Oncology, JCR 2018) (Corresponding author)
  20. Mao B-H, Chen Z-Y, Wang Y-J*, Yan S-J*. Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Sci Rep. 2018 Feb 5;8(1):2445. (SCI IF=4.011 rank: 15/69 =21.74% in Multidisciplinary sciences, JCR 2018) (Corresponding author)
  21. Chen R-J, Kuo H-C, Cheng L-H, Lee Y-H, Chang W-T, Wang B-J, Wang Y-J*, Cheng H-C*. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer. Int J Mol Sci. 2018 Jan 18;19(1). (SCI IF=4.183 rank: 42/172=24.42% in Chemistry, Multidisciplinary, JCR 2018) (Corresponding author)
  22. Wu J-C, Tsai M-L, Lai C-S, Lo C-Y, Ho C-T, Wang Y-J*, Pan M-H*. Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism and ameliorate autophagic defect in ICR mice. Int J Cancer. 2018 Apr 15;142(8):1689-1701. (SCI IF=4.982 rank: 51/229=22.27% in Oncology, JCR 2018) (Corresponding author)
 
 

研討會論文

1. Ying-Jan Wang. Autophagy could be an early biomarker of nanotoxicity in safety assessment-related alternative testing strategies: Take the silver nanoparticle for example. 3rd IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability, Tainan, Taiwan. May 29, 2021. (Keynote speaker)
2. Ying-Jan Wang, Shih-Yi Hun, Yu-Hsuan Lee and Hui-Wen Chiu. ER stress triggered autophagy may contribute to the enhanced immune response of nanoparticles in an allergic contact dermatitis animal model induced by chromium (VI). 5th International Earth Science, Geology, Oil and Gas Conference. Kuala Lumpur, Malaysia. Dec 2-3, 2019. (Keynote speaker)
3. Ying-Jan Wang. Toxic effects of Silver nanoparticle with regard to hazard identification and safety evaluation. 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications, Columbus, OH, USA. July 29-31, 2019. (Invited speaker)
4. Yi-Chun Yang, Yu-Hsuan Lee and Ying-Jan Wang. Applying zebrafish model as an alternative test method for developmental toxicity of zinc oxide nanoparticles. The 2nd International Conference and Expo on Green Chemistry and engineering, Barcelona, Spain. July. 23-24, 2018. (Invited speaker)
5. Yu-Hsuan Lee and Ying-Jan Wang. Toxicological evaluation of silver nanoparticle with regard to hazard identification and safety management. The 8th International Congress of Asian Society of Toxicology (AsiaTox), Pataya, Thailand. June 17-20, 2018. (Invited speaker-1)
6. Rong-Jane Chen, Min-Hsiung Pan and Ying-Jan Wang. Pterostilbene and lung cancer: The possible molecular mechanisms involved in its chemoprevention effects. The 8th International Congress of Asian Society of Toxicology (AsiaTox), Pataya, Thailand. June 17-20, 2018. (Invited speaker-2)
 

專書

1. Ying-Jan Wang. Prevention of Occupational and Environmental Exposures, in: A. Murat Tuncer (ed.): Cancer Report of Asian-Pacific Region . 2010.
2. 郭育良、王應然、許昺奇、郭浩然、蔡朋枝、蘇德勝、王士旻、黃奕孝（2012年07月）。職業與疾病。華杏出版股份有限公司。
3. Wang Y-J and Chen R-J. CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, Ch27 Pterostilbene Protection and Bladder Cancer Cells. First edition 2014, Copyright © 2014 Elsevier Inc.
4. Ying-JanWang. Nanotoxicology and Nanosafety 2.0 International Journal of Molecular Sciences, 2020.
 
 
 
 
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