專長與研究領域

• 職業衛生
• 暴露評估
• 健康風險評估
• 職業流行病學
• 環境流行病學
• 環境衛生
• 噪音污染與健康影響
• 揮發性有機物暴露與風險評估
• 微型感測器與人工智慧監測
• 環境與職業暴露評估模式(土地利用迴歸模式、個人職業暴露預測模式)

開授課程

• 工業與環境衛生
• 環境與職業衛生
• 作業環境監測
• 暴露與風險評估
• 職業衛生與健康管理實務

學歷

• 國立臺灣大學職業醫學與工業衛生研究所 博士
• 國立臺灣大學職業醫學與工業衛生研究所 碩士
• 國立臺灣大學公共衛生學系 學士

經歷

• 國立成功大學工業衛生學科暨環境醫學研究所 教授 (2026.08~迄今)
• 中國醫藥大學公共衛生學院 副院長 (2017.02~2021.07)
• 中國醫藥大學公共衛生學院大一不分系  系主任  (2018.08~2020.0)
• 中國醫藥大學職業安全與衛生學系  系主任  (2015.08~2021.07)
• 中國醫藥大學環安室  主任  (2015.08~2021.07)
• 中國醫藥大學職業安全與衛生學系 教授  (2013.08~2026.07)
• 荷蘭Utrecht University風險評估科學研究所  訪問學者  (2011.08-2012.07)
• 中國醫藥大學職業安全與衛生學系 副教授  (2009.08-2013.08)
• 中國醫藥大學職業安全與衛生學系 助理教授  (2004.08-2009.07)

近五年學術著作

期刊論文

1. Lin JY, Jung CR, Hung CI, Hwang BF, Chang TY* (2026) Occupational exposure and incidence of female breast cancer at different stages in Taiwan. Cancer Epidemiology, 104:103189.
2. (2)    Chang TY, Su TC, Chien YC (2026) Influences of Coffee Processing Stages and Variables on the Formation of Diacetyl and 2,3-pentanedione: A Field Assessment in a Cafe? Setting. ACS Chemical Health & Safety, 33(4): 607-617.
3. (3)    Tran XN, Lee YL, Lin YC, Chang TY, Chang LT, Ho KF, Chuang KJ, Chung KF, Chang JH, Chuang HC (2026) Associations of meteorological factors and obesity on pediatric asthma hospitalization. Pediatric Research, 99(5):1913-1919.
4. (4)    Tsai CH, Chien YC, Liu CS, Chang TY* (2026) Occupational Noise Exposure Assessed by High-Frequency Hearing Loss and its Association with Hypertension among Air Force Ground Staff. Noise and Health, 28(132):744-755.
5. (5)    Dinh CT, Lee YL, Chang LT, Chang TY, Chung KF, Lee KY, Chang JH, Chuang HC (2026) Assessing the impact of air pollution on anemia: a comprehensive review and meta-analysis. Expert Review of Hematology, (5):529-538. 
6. (6)    Tsai CH, Chien YC, Chang TY* (2026) Associations Between Noise-Induced Hearing Loss and the Risk of High Fasting Blood Glucose Among the Air Force Population. Safety and Health at Work, 17(1):56-63.
7. (7)    Zhung TY, Chen WJ, Yang YJ, Chang TY* (2025) Air pollutants, temperature, and road traffic noise: their impact on chronic kidney disease incidence in older individuals in Taiwan. Environmental Research, 286(1):122782.
8. Lin JY, Hung CI, Li TC, Chang TY* (2025) Development and validation of a Chinese version of a questionnaire to evaluate the knowledge, attitude, and practice about breast cancer screening among financial female workers in Taiwan. Frontiers in Oncology, 15:1559622. 
9. (9)    Chang TY, Zhuang TY, Yang YC, Hsu CC, Cheng WJ* (2025) The increased risk of exposure to fine particulate matter for depression incidence is mediated by elevated TNF-R1: the Healthy Aging Longitudinal Study. Environmental Health and Preventive Medicine, 30:49.
10. (10)    Wang TB, Chen JJ, Chang TY* (2025) Spatial determinations and application of land?use regression models to evaluate outdoor volatile organic compounds in Taiwan. Air Quality, Atmosphere and Health, 18(7), 2097-2109. 
11. (11)    Lee, YL; Heriyanto, DS; Yuliani, FS; Laiman, V; Choridah, L; Lee, KY; Chang, JH; Chung, KF; Chang, LT; Chang, TY; Chen, XY; Peng, SW; Chuang, KJ; Chuang, HC* (2024). Eosinophilic inflammation: a key player in COPD pathogenesis and progression. Annals of Medicine, 56(1): 2408466.
12. (12)    Chen, JJ; Wang, TB; Chang, LT; Chuang, KJ; Chuang, HC; Chang, TY* (2024) Exposure and health risk assessment of volatile organic compounds among drivers and passengers in long-distance buses. Environmental Research, 252(3):118959.
13. (13)    Wang, AB; Chuang, KJ; Wang, VS; Chang, TY* (2024) Personal exposure to sulfuric acid in the electroplating industry: development and validation of a predictive model. Toxics, 12(7): 489.
14. (14)    Wang, TC; Yu, YC; Hsu, A; Lin, JY; Tsou, YA; Liu, CS; Chuang, KJ; Pan, WC; Yang, CA; Hu, SL; Ho, CY; Chen, TL; Lin, CD; Pai, PY; Chang, TY* (2024) Impact of occupational noise exposure on the hearing level in hospital staffs: a longitudinal study. Environmental Science and Pollution Research, 31(16):24129-24138. 
15. (15)    Chang, JH; Lee YL; Chang, LT; Chang, TY; Hsiao TC; Chung, KF; Ho, KF; Kuo, HP; Lee, KY; Chuang, KJ; Chuang, HC* (2023) Climate change, air quality, and respiratory health: a focus on particle deposition in the lungs. Annals of Medicine, 55(2):2264881.
16. (16)    Chang, TY*; Chen, GY; Chen, JJ; Young, LH; Chang, LT (2023) Application of artificial intelligence algorithms and low-cost sensors to estimate respirable dust in the workplace. Environment International, 182:108317. 
17. (17)    Huan, MT; Tsai, FJ; Lee, YL; Chang, JH; Chang, LT; Chang, TY; Chung, KF; Kuo, HP; Lee, KY; Chuang, KJ; Chuang, HC* (2023) The impact of air pollution on respiratory diseases in an era of climate change: A review of the current evidence. Science of the Total Environment, 898:166340. 
18. (18)    Cho, CI; Chen, JJ; Chuang, KJ; Chuang, HC; Wang, IJ; Chang, TY* (2023) Associations of particulate matter, gaseous pollutants, and road traffic noise with the prevalence of asthma in children. Chemosphere, 338:139523. 
19. (19)    Bai, KJ; Liu, WT; Lin, YC; He, Y; Lee, YL; Wu, D; Chang, TY; Chang, LT; Lai, CY; Tsai, CY; Chung, KF; Ho, KF; Chuang, KJ; Chuang, HC* (2023) Ambient relative humidity-dependent obstructive sleep apnea severity in cold season: A case-control study. Science of the Total Environment, 861:160586. 
20. (20)    Lin, JY; Chen, WJ; Wu, CF; Chang, TY* (2023) Associations of road traffic noise and its frequency spectrum with prevalent depression in Taichung, Taiwan. Frontiers in Public Health, 11:1116345. 
21. (21)    Chang, LT; Mai, CJ; Yang, SY; Chang, TY* (2022) Exposure to volatile organic compounds and risk perception among workers: An industry-based cross-sectional survey. Human and Ecological Risk Assessment: An International Journal, 28:10, 1105-1123. (SCI, Impact factor:4.3; Ranking in ENVIRONMENTAL SCIENCES=100/275=36.36% (Q2) in JCR2022)
22. (22)    Wu, CC; Tsai, CY; Chuang, HC; Chang, TY* (2022) Development and performance evaluation of a mixed-sensor system for fine particles and road traffic noise. Environmental Technology & Innovation, 28:102902.
23. (23)    Cheng, CA; Ching, TC; Tsai, SW; Chuang, KJ; Chuang, HC; Chang, TY* (2022) Exposure and health risk assessment of indoor volatile organic compounds in a medical university. Environmental Research, 213:113644. (2022) (S.C.I. IF: 10.6. Subject Category: 28/395=7.1% in Environmental Sciences, JCR 2025)
24. (24)    Lo, CC; Liu, WT; Lu, YH; Wu, D; Wu, CD; Chen, TC; Fang, YT; Lo, YC; Chen, YY; Kang, L; Tsai, CY; Lee, YL; Chuang, KJ; Ho, KF; Chang, TY; Chuang, HC* (2022) Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults, Environmental Science and Pollution Research, 29(35), 52355-52366. 
25. (25)    Liu, WT; Wang, YH; Chang, LT; Wu, CD; Wu, D; Tsai, CY; Lo, CC; Lo, K; Chung, KF; Chang, TY; Chuang KJ; Lee, YL; Chuang, HC* (2022) The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults. Environmental Science and Pollution Research, 29(33), 50755-50764.
26. (26)    Chang, LT; Liu, IJ; Chang, TY; Hong, GB; Lin, LY; Chuang, HC; Ho, KF; Chuang, KJ* (2022) Association of long-term indoor exposure to fine particles with pulmonary effects in Northern Taiwan. Science of the Total Environment, 821, 153097.
27. (27)    Wang, TC; Chiu, CJ; Chen, PC; Chang, TY*; Tyler, RS; Rojas-Roncancio, E; Coelho, CB; Mancini, PC; Lin, CL; Lin, CD; Tsai, MH (2021) Increased Incidence of Tinnitus Following a Hyperthyroidism Diagnosis: A Population-Based Longitudinal Study. Frontiers in Endocrinology, 12:741719.
28. (28)    Wang, TC; Chang, TY*; Tyler, RS; Hwang, BF; Chen, YH; Wu, CM; Liu, CS; Chen, KC; Lin, CD; Tsai, MH (2021) Association between exposure to road traffic noise and hearing impairment: a case-control study. Journal of Environmental Health Science and Engineering, 19, 1483-1489.
29. (29)    Wang, CY; Wang, TC; Liang, WM; Hung, CH; Chiou, JS; Chen, CJ; Tsai, FJ; Huang, ST; Chang, TY; Lin, TH; Liao, CC; Huang, SM; Li, TM; Lin, YJ (2021) Effect of Chinese herbal medicine therapy on overall and cancer related mortality in patients with advanced nasopharyngeal carcinoma in Taiwan. Frontiers in Pharmacology, 11.
30. (30)    Chang, LT; Lee, YL; Yuan, TH; Chang, JH; Chang, TY; Lee, CH; Ho, KF; Chuang, HC (2021) Hepatotoxicity Caused by Repeated and Subchronic Pulmonary Exposure to Low-Level Vinyl Chloride in Mice. Atmosphere, 12, 596.
31. (31)    Chen, XY; Feng, PH; Chen, YY; Wu, CD; Wu, SM; Lee, KY; Kuo, HP; Hsiao TC; Chen, KY; Ho, SC; Chang, TY; Lee, IT; Chuang*, HC (2021) Alveolar epithelial inter-alpha-trypsin inhibitor heavy chain 4 deficiency associated with senescence-regulated apoptosis by air pollution. Environmental Pollution, 278: 116863.
32. (32)    Chang, TY*; Tsai CC; Wu CF; Chang LT; Chuang KJ; Chuang HC; Young L.H (2021) Development of land-use regression models to estimate particle mass and number concentrations in Taichung, Taiwan. Atmospheric Environment, 252:118303.
33. 陳靖傑、張立德、張大元(Ta-Yuan Chang)*，生成式人工智慧在職業健康風險評估的展望，台灣公共衛生雜誌/Taiwan Journal of Public Health，2025 Aug，44(4):328-337，TSSCI。
34. 陳靖傑(Chen, Jing-Jie)、張大元(Ta-Yuan Chang)*，揮發性有機化合物暴露與失智症風險之相關性：回溯性世代研究，台灣公共衛生雜誌/Taiwan Journal of Public Health，2023 Dec，42(6):663-677，TSSCI。
35. 林佳儀(Lin, Jia-Yi)、(Ching–I Hung)、鍾朝仁(Chau-Ren Jung)、黃彬芳(Hwang, Bing-Fang)、張大元(Ta-Yuan Chang)*，我國女性勞工乳癌發生率、篩檢率及存活率之探討，勞動及職業安全衛生研究季刊/Journal of Lavor, Occupational Safety and Health，2022 Dec，30(4):54-66，ACI。