專長與研究領域

• 藥物研發
• 毒理檢測應用
• 毒性判斷
• 環境毒理

開授課程

• 環境毒物學
• 進階毒理學

學歷

• 美國阿拉巴馬大學伯明翰分校環境毒理博士（1992年9月-1996年6月）
• 國立陽明大學生理學研究所碩士（1986年9月-1988年6月）
• 高雄醫學大學藥學系學士（1982年9月-1986年6月）

經歷

• 財團法人生物技術開發中心藥物平台所所長（2020-）
• Samumed LLC, San Diego, California, Director, Toxicology（2018-2020）
• Samumed LLC, San Diego, California, Assoc. Director, Toxicology（2015-2018）
• National Research Center for Biopharmaceuticals, Taipei, Taiwan, Preclinical Consultant（2013-2015）
• Anacor Pharmaceuticals, Mountain View, Director, Toxicology（2010-2013）
• Anacor Pharmaceuticals, Mountain View, Assoc. Director, Toxicology（2008-2010）
• Alexza Pharmaceuticals, Palo Alto, California, Sr. Scientist/ Toxicologist, Toxicology Department（2007-2008）
• ALZA Corporation, JNJ, Mountain View, California, Sr. Research Scientist/ Assoc. Director, Nonclinical Research and Development（2005-2007）
• Roche Bioscience, Palo Alto, California, Research Scientist/ Project Toxicologist, Department of Toxicology（2002-2005）
• Scientific Advisor, MicroBio Co, Taipei, Taiwan（2001-2002）
• Principal Investigator, Research Fellow and Study Director, Toxicology Program, Development Center for Biotechnology, Taipei, Taiwan（1996-2001）
   

著作

期刊論文

1. Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals. Roy,D., Palangat, M., Chen, CW., Thomas, RD., Colerangle, J., Atkinson, A. and Yan, ZJ. (1997) J. Toxicol. Environ. Health 50:1-29.
2. Inhibition of stilbene estrogen-induced cell proliferation of renal epithelial cells through the modulation of insulin-like growth factor-I receptor expression. Chen, CW., Oberley, TD. and Roy, D. (1996) Cancer Letter 19; 105: 51-59.
3. Mechanism of antiproliferative activity of luteolin against stilbene-estrogen stimulation of proliferation of hamster renal epithelial cells. Chen, CW., Palangat, M., Oberley, TD. and Roy, D. (1996) International J. Oncology 9:811-814.
4. Up regulation of nuclear IGF-I receptor by short-term exposure of stilbene estrogen, diethylstilbestrol. Chen, CW., and Roy, D. (1996) Cellular and Molecular Endocrinology 118:1-8.
5. Activation of the phosphorylation of the plasma membrane insulin-like growth factor-I receptors in the target organ of cancer by diethylstilbestrol. Chen, CW., and Roy, D. (1995) Carcinogenesis 6:1339-1344.
6. Decreased norepinephrine release in anterior hypothalamus of NaCl-sensitive SHR (SHR-S) following high NaCl intake. Chen, CW., Chen, YF., Meng, QC., Wyss, JM. And Oparil, S. (1991) Brain Research 565:135-141.
7. Increased plasma prolactin levels in ovariectomized, thyroidectomized rats treated with estrogen. Pan, JT and Chen. CW. (1990). Endocrinology 126:3146-3152.

研討會論文

1. Reproductive and Developmental Toxicity Studies Demonstrate that AN2728, a Novel Boron-Containing Small Molecule, is neither a Reproductive Toxicant nor a Teratogen. C-W. Chen, V. Sharper, and S. Chanda (2012) The 51st Society of Toxicology Anniversary Annual Meeting. Abstract # 2252.
2. Animal Screening Models for PDE4 Inhibitor-Induced Toxicity C-W. Chen, H. Sexton, K Jarnagin, X-Q. Fan, W. Bu, A. Wu, Y. Freund and S. Chanda (2011) The 50th Society of Toxicology Anniversary Annual Meeting. Abstract # 542.
3. Application of Animal Models for AN0128 Topical Formulations Development. Chen, C-W, Imbert, D and Chanda, S. (2009) Thirteen Annual Meeting of the American College of Toxicology.
4. Evaluation of Reproductive Toxicity of Dehulled Adlay in Rats. Yang MF, Wong ML, Wong CP and Chen, CW. (2001) The 5th ACPA International Conference: Bring Asian Herbal and Traditional Medicines to the Modern Mainstream Pharmaceutical World.
5. Development Center for Biotechnology in Taiwan. Chou, BJ and Chen, CW. (2001) The 5th ACPA International Conference: Bring Asian Herbal and Traditional Medicines to the Modern Mainstream Pharmaceutical World.
6. Development Center for Biotechnology’s experience in toxicology for herbal medicine. Chou, BJ and Chen, CW. (2001) The 5th ACPA International Conference: Bring Asian Herbal and Traditional Medicines to the Modern Mainstream Pharmaceutical World.
7. Up-regulation of nuclear receptor by short-term exposure of stilbene estrogen. Chen, CW. and Roy, D. (1995) Proceedings of the American Association for Cancer Research 36:.2774.
8. Attenuation in DNA repair system coupled with increased cell proliferation lead to enhanced genetic instability: A possible mechanism of estrogen-induced carcinogenesis. Roy. D., Chen, CW., Purewal, M. and Yan, ZJ. (1994) Canadian J. of Pharmacology 72, supp. 1:22.3.038.
9. Up-regulation of kidney insulin like growth factor-I (IGF-I) receptors by estrogen. Chen, CW. and Roy, D. (1994) The Toxicologist 14:457.
10. Overexpression of membrane tyrosine containing phosphoproteins in the target organ of cancer by estrogen. Chen, CW. and Roy, D. (1994). Proceedings of the American Association for Cancer Research 35:1551.
11. Attenuation of diethylstilbestrol metabolism by thiol. Chen, CW. and Roy, D. (1993) Proceedings of the American Association for Cancer Research 34:934.
12. The effect of captopril on myocardial hypertrophy and myocyte remodeling in abdominal aortic constricted rats. Bishop, SP., Chen, CW., Doss, L. and Sreean, G. (1992) J. of Molecular Cellular Cardiology 24: 94a.
13. Decreased norepinephrine release in anterior hypothalamus of NaCl-sensitive SHR (SHR-S) following high NaCl intake. Chen, CW., Chen, YF., Meng, QC., Wyss, JM. And Oparil, S. (1990) Hypertension 16:322.
14. Small dose doperidone potentiated the effects of TRH and serotonin on prolactin secretion in estrogen-treated, ovariectomized rats. Pan, JT., Tea, KL. and Chen, CW. (1988). Soc. Neurosci. Abstr 14:74.
15. Studies on the mechanisms of hyperprolactinemia in thyroidectomized, ovariectomized rats treated with estrogen. .Chen, CW. and Pan, JT. (1988) The 3rd Joint Annual Conference of Biomedical Science , Abstr 106.