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Hui-Wen Chiu

Hui-Wen Chiu

Hui-Wen Chiu

Professor

Ph.D., Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University

Tel： +886-6-235-3535 ext. 5805

Email：hwchiu@gs.ncku.edu.tw

Research NCKU

Speciality and Domain

  • Environmental and Molecular Toxicology
  • Cellular and Molecular Biology
  • Kidney and Metabolic Disease Therapeutics
  • Multi-Omics and Precision Medicine
  • Cancer Biology

Course

  • Environmental Toxicology
  • Chemical Carcinogenesis
  • Experimental Toxicology
  • Advanced Toxicology

Education

  • Ph.D., Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University
  • M.S., Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University

Experience

  • Professor, Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University (2026/08~Present)
  • Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University (2021/08~2026/07)
  • Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
  • Assistant Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
  • Postdoctoral Fellow, Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University

Publication

 

Papers

  1. H-J Huang#, P-T Wu#, L-C Sung, C-M Zheng* and H-W Chiu*. Impact of vascular access type and obesity on long-term thrombosis and access failure in hemodialysis: A real-world cohort study from the TriNetX global collaborative network. Biomedicines 14, 1380 (2026). (S.C.I. IF: 4.5. Subject Category: 90/356=25.3% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  2. R-Y Su, H-C Chuang, C-M Zheng, L-J Ho, Y-J Chen, Y-H Lee* and H-W Chiu*. Urban particulate matter induces NLRP3/NLRP6 inflammasomes, autophagy, senescence and fibrotic responses by increasing CSF2 signaling in kidney cells. Free Radical Biology & Medicine 249, 1-13 (2026) (S.C.I. IF: 8.0. Subject Category: 17/198=8.6% in Endocrinology & Metabolism, JCR 2025) (Corresponding author) 
  3. C-T Liao, Y-C Lin, H-J Huang, W-C Liu*, W-C Kan* and H-W Chiu*. Docking and database screening identify manidipine as a potential modulator of matrix metalloproteinase-7 in chronic kidney disease. Biomedicine & Pharmacotherapy 193, 118748 (2025) (S.C.I. IF: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (Corresponding author)
  4. H-J Huang#, Y-C Lin#, L-J Ho, R-Y Su, W-C Liu* and H-W Chiu*. Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury. European Journal of Pharmaceutical Sciences 214, 107296 (2025) (S.C.I. IF: 5.1. Subject Category: 65/356=18.3% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  5. H-Y Lin, W-K Wang, C-H Lin, C-H Kuei, H-H Lee, Y-H K Lin, H-W Chiu* and Y-F Lin*. The IL-8/NF-κB feedback loop confers a paclitaxel-sensitive/doxorubicin-resistant phenotype in triple-negative breast cancer. Free Radical Biology & Medicine 238, 316-328 (2025) (S.C.I. IF: 8.0. Subject Category: 17/198=8.6% in Endocrinology & Metabolism, JCR 2025) (Corresponding author)
  6. H-W Chiu, C-C Shih, H-J Huang, T-H Huang and L-C Sung*. Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway. Biomedicine & Pharmacotherapy 189, 118275 (2025) (S.C.I. IF: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (First author) 
  7. Y-L Wang#, Y-C Lin#, W-C Liu, Y-H Lee* and H-W Chiu*. Air pollution and its impacts on health: Focus on microplastics and nanoplastics. Ecotoxicology and Environmental Safety 299, 118402 (2025) (S.C.I. IF: 6.6. Subject Category: 9/106=8.5% in Toxicology, JCR 2025) (Corresponding author)
  8. Y-H Lee, C-M Zheng, Y-J Wang, Y-L Wang and H-W Chiu*. Effects of microplastics and nanoplastics on the kidney and cardiovascular system. Nature Reviews Nephrology 21, 585–596 (2025) (S.C.I. IF: 46.7, 1/134=0.75% in Urology & Nephrology, JCR 2025) (Corresponding author)「Cover」
  9. C-K Chen, H-W Chiu, H T Nguyen, H-T Lu* and A E.-Y. Chuang*. Transdermally administered nanozymes-infused F127/methylcellulose hydrogel for osteoarthritis relief via immunomodulatory pathways. Journal of Biological Macromolecules 314, 144114, 2025 (S.C.I. IF: 8.7. Subject Category: 6/96=6.3% in Polymer Science, JCR 2025)
  10. H-W Chiu, C-W Chu, C-C Huang, Z-C Chia, Y-L Wang, Y-H Lee*. Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway. Environmental Pollution 369, 125850 (2025) (S.C.I. IF: 7.2. Subject Category: 68/395=17.2% in Environmental Sciences, JCR 2025) (First author) 
  11. H-W Chiu#, K-C Lu#, Y-C Lin, Y-C Hou, M-T Liao, Y-J Chen, Y-J Chiu and C-M Zheng*. Etelcalcetide ameliorates bone loss in chronic kidney disease-mineral and bone disorder by activation of IRF7 and necroptosis pathways. International Journal of Biological Macromolecules 280, 135978 (2024) (S.C.I. IF: 8.7. Subject Category: 6/96=6.3% in Polymer Science, JCR 2025) (First author) 
  12. H-W Chiu, C-L Chou, K-T Lee, C-C Shih, T-H Huang and L-C Sung*. Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1. International Journal of Biological Macromolecules 268, 131779 (2024) (S.C.I. IF: 8.7. Subject Category: 6/96=6.3% in Polymer Science, JCR 2025) (First author)
  13. Y-L Wang, Y-H Lee, C-L Chou, Y-S Chang, W-C Liu and H-W Chiu*. Oxidative stress and potential effects of metal nanoparticles: a review of biocompatibility and toxicity concerns. Environmental Pollution 346, 123617 (2024) (S.C.I. IF: 7.2. Subject Category: 68/395=17.2% in Environmental Sciences, JCR 2025) (Corresponding author)
  14. Y-L Wang#, C C-Y Huang, C-M Zheng, W-C Liu, Y-H Lee# and H-W Chiu*. Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts. Ecotoxicology and Environmental Safety 273, 116098 (2024) (S.C.I. IF: 6.6. Subject Category: 9/106=8.5% in Toxicology, JCR 2025) (Corresponding author)
  15. H-W Chiu#, H-L Lee, H-H Lee, H-W Lu, Y-H K Lin, Y-F Lin# and C-H Lin*. AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma. Journal of Translational Medicine 22, 13 (2024) (S.C.I. IF: 9.7. Subject Category: 20/191=10.5% in Medicine, Research & Experimental, JCR 2025) (First author) 
  16. H-J Huang#, C-L Chou, T T Sandar, W-C Liu, H-C Yang, Y-C Lin#, C-M Zheng* and H-W Chiu*. Currently used methods to evaluate the efficacy of therapeutic drugs and kidney safety. Biomolecules 13, 1581 (2023) (S.C.I. IF: 5.6. Subject Category: 72/328=22.0% in Biochemistry & Molecular Biology, JCR 2025) (Corresponding author)
  17. H-J Huang#, Y-H Lee, L-C Sung, Y-J Chen, Y-J Chiu, H-W Chiu# and C-M Zheng*. Drug repurposing screens to identify potential drugs for chronic kidney disease by targeting prostaglandin E2 receptor. Computational and Structural Biotechnology Journal 21, 3490–3502 (2023) (S.C.I. IF: 4.8. Subject Category: 92/328=28.0% in Biochemistry & Molecular Biology, JCR 2025) (First author) 
  18. T-Z Yuan, H-Y Lin, C-H Kuei, C-H Lin*, H-H Lee, H-L Lee, H-W Lu, C-Y Su, H-W Chiu* and Y-F Lin*. NEDD8 promotes radioresistance via triggering autophagy formation and serves as a novel prognostic marker in oral squamous cell carcinoma. Cancer Cell International 23, 41 (2023) (S.C.I. IF: 7.0. Subject Category: 54/333=16.2% in Oncology, JCR 2025) (Corresponding author) 
  19. W-C Liu, H-W Chiu, C-L Chou, Y-J Chiu and Y-H Lee*. Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis. Environmental Pollution 318, 120871 (2023) (S.C.I. IF: 7.2. Subject Category: 68/395=17.2% in Environmental Sciences, JCR 2025) 
  20. Y-H Wu#, R-J Chen#, H-W Chiu, L-X Yang, Y-L Wang, Y-Y Chen, Y-L Yeh, M-Y Liao* and Y-J Wang*. Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy. Theranostics 13, 40-58 (2023). (S.C.I. IF: 14.9. Subject Category: 6/191=3.1% in Medicine, Research & Experimental, JCR 2025)
  21. C-M Zheng, K-C Lu, Y-J Chen, C-Y Li, Y-H Lee* and H-W Chiu*. Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy. Biomedicine & Pharmacotherapy 154, 113565 (2022). (S.C.I. IF: 7.5. Subject Category: 19/352=5.4% in Pharmacology & Pharmacy, JCR 2024) (Corresponding author)
  22. H-J Huang, Y-H Lee, C-L Chou, C-M Zheng* and H-W Chiu*. Investigation of potential descriptors of chemical compounds on prevention of nephrotoxicity via QSAR approach. Computational and Structural Biotechnology Journal 20, 1876-1884 (2022). (S.C.I. IF: 4.8. Subject Category: 92/328=28.0% in Biochemistry & Molecular Biology, JCR 2025) (Corresponding author)
  23. C-W Lee, L-F Hsu, I-L Wu, Y-L Wang, W-C Chen, Y-J Liu, L-T Yang, C-L Tan, Y-H Luo, C-C Wang, H-W Chiu, TC-K Yang, Y-Y Lin, H-A Chang, Y-C Chiang, C-H Chen, M-H Lee, K-T Peng, CC-Y Huang*. Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice. Journal of Hazardous Materials 430, 128431 (2022) (S.C.I. IF: 10.6. Subject Category: 28/395=7.1% in Environmental Sciences, JCR 2025)
  24. H-W Chiu, Y-C Hou, C-L Lu, K-C Lu, W-C Liu, J-F Shyu, J-F Chang, C-M Zheng*. Cinacalcet improves bone parameters through regulation of osteoclast endoplasmic reticulum stress, autophagy, and apoptotic pathways in chronic kidney disease-mineral and bone disorder. Journal of Bone and Mineral Research 37, 215-225 (2022) (S.C.I. IF: 6.5. Subject Category: 29/198=14.6% in Endocrinology & Metabolism, JCR 2025) (First author)
  25. J-Q Zheng, C-H Lin, H-H Lee, W-K Wang, Y-S Tong, K-Y Lee, H-W Chiu* and Y-F Lin*. Lactotransferrin downregulation serves as a potential predictor for the therapeutic effectiveness of mTOR inhibitors in the metastatic clear cell renal cell carcinoma without PTEN mutation. Biomedicines 9, 1896 (2021). (S.C.I. IF: 4.5. Subject Category: 90/356=25.3% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  26. Y-L Wang, C-M Zheng, Y-H Lee, Y-Y Cheng, Y-F Lin and H-W Chiu*. Micro- and nanosized substances cause different autophagy-related responses. International Journal of Molecular Sciences 22, 4787 (2021). (S.C.I. IF: 5.6. Subject Category: 72/328=22.0% in Biochemistry & Molecular Biology, JCR 2025) (Corresponding author)
  27. Y-L Wang#, Y-H Lee, Y-H Hsu, I-J Chiu, C C-Y Huang, C-C Huang, Z-C Chia, C-P Lee, Y-F Lin# and H-W Chiu*. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL/6 mice. Environmental Health Perspectives 129, 57003 (2021) (S.C.I. IF: 10.9. Subject Category: 11/443=2.5% in Public, Environmental & Occupational Health, JCR 2025) (Corresponding author)
  28. H-J Huang, Y-H Lee, Y-H Hsu, C-T Liao, Y-F Lin* and H-W Chiu*. Current strategies in assessment of nanotoxicity: Alternatives to in vivo animal testing. International Journal of Molecular Sciences 22, 4216 (2021). (S.C.I. IF: 5.6. Subject Category: 72/328=22.0% in Biochemistry & Molecular Biology, JCR 2025) (Corresponding author)
  29. Y-H Hsu#, C-M Zheng, C-L Chou, Y-J Chen, Y-H Lee#, Y-F Lin* and H-W Chiu*. Therapeutic effect of endothelin-converting enzyme inhibitor on chronic kidney disease through the inhibition of endoplasmic reticulum stress and the NLRP3 inflammasome. Biomedicines 9, 398 (2021). (S.C.I. IF: 4.5. Subject Category: 90/356=25.3% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  30. M-S Sun, L-T Yuan, C-H Kuei, H-Y Lin, Y-L Chen, H-W Chiu* and Y-F Lin*. RGL2 drives the metastatic progression of colorectal cancer via preventing the protein degradation of -catenin and KRAS. Cancers 13, 1763 (2021). (S.C.I. IF: 4.8. Subject Category: 92/333=27.6% in Oncology, JCR 2025) (Corresponding author)
  31. S-W Cheng, P-C Chen, M-H Lin, T-R Ger, H-W Chiu* and Y-F Lin*. GBP5 repression suppresses the metastatic potential and PD-L1 expression in triple-negative breast cancer. Biomedicines 9, 371 (2021). (S.C.I. IF: 4.5. Subject Category: 90/356=25.3% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  32. S-W Cheng, P-C Chen, T-R Ger, H-W Chiu* and Y-F Lin*. GBP5 serves as a potential marker to predict a favorable response in triple-negative breast cancer patients receiving a taxane-based chemotherapy. Journal of Personalized Medicine 11, 197 (2021) (Corresponding author) 
  33. F-Y Cheng#, C-H Chan#, B-J Wang, Y-L Yeh, Y-J Wang* and H-W Chiu*. The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer. Cancers 13, 606 (2021). (S.C.I. IF: 4.8. Subject Category: 92/333=27.6% in Oncology, JCR 2025) (Corresponding author) 
  34. C-M Zheng#, Y-H Lee, I-J Chiu, Y-J Chiu, L-C Sung#, Y-H Hsu* and H-W Chiu*. Nicotine causes nephrotoxicity through the induction of NLRP6 inflammasome and alpha7 nicotinic acetylcholine receptor. Toxics 8, 92 (2020) (S.C.I. IF: 4.9. Subject Category: 21/106=19.8% in Toxicology, JCR 2025) (Corresponding author)
  35. Y-H Hsu, I-J Chiu, Y-F Lin, Y-J Chen, Y-H Lee and H-W Chiu*. Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis. Pharmaceutics 12(5), 434 (2020). (S.C.I. IF: 6.9. Subject Category: 34/356=9.6% in Pharmacology & Pharmacy, JCR 2025) (Corresponding author)
  36. I-J Chiu, Y-H Hsu, J-S Chang, J-C Yang, H-W Chiu* and Y-F Lin*. Lactotransferrin downregulation drives the metastatic progression in clear cell renal cell carcinoma. Cancers 12, 847 (2020). (S.C.I. IF: 4.8. Subject Category: 92/333=27.6% in Oncology, JCR 2025) (Corresponding author)
  37. Y-L Wang, Y-H Lee, I-J Chiu, Y-F Lin* and H-W Chiu*. Potent impact of plastic nanomaterials and micromaterials on the food chain and human health. International Journal of Molecular Sciences 21(5), 1727 (2020). (S.C.I. IF: 5.6. Subject Category: 72/328=22.0% in Biochemistry & Molecular Biology, JCR 2025) (Corresponding author)
  38. H-W Chiu, Y-L Yeh, S-Y Ho, Y-H Wu, B-J Wang, W-J Huang, Y-S Ho, Y-J Wang, L-C Chen and S-H Tu. A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer. Cancers 11, 1703 (2019). (S.C.I. IF: 4.8. Subject Category: 92/333=27.6% in Oncology, JCR 2025) (First author)
  39. Y-H Hsu#, H-C Chuang, Y-H Lee, Y-F Lin, Y-J Chiu, Y-L Wang#, M-S Wu*and H-W Chiu*. Induction of fibrosis and autophagy in kidney cells by vinyl chloride. Cells 8, 601 (2019). (S.C.I. IF: 6.0. Subject Category: 59/207=28.5% in Cell Biology, JCR 2025) (Corresponding author)
  40. Y-F Lin#, J-L Chou, J-S Chang, I-J Chiu, H-W Chiu#, and Y-F Lin*. Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma. EBioMedicine 45, 220-230 (2019). (S.C.I. IF: 11.2. Subject Category: 19/191=9.4% in Medicine, Research & Experimental, JCR 2025) (First author)
  41. Y-H Hsu#, H-C Chuang, Y-H Lee, Y-F Lin, Y-J Chen, T-C Hsiao, M-Y Wu# and H-W Chiu*. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radical Biology & Medicine 135, 235-244 (2019) (S.C.I. IF: 8.0. Subject Category: 17/198=8.6% in Endocrinology & Metabolism, JCR 2025) (Corresponding author) 
  42. Y-H Wu#, W-S Wu, L-C Lin, C-S Liu, S-Y Ho, B-J Wang, B-M Huang, Y-L Yeh, H-W Chiu#, W-L Yang* and Y-J Wang*. Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation. Journal of Experimental & Clinical Cancer Research 37:91 (2018). (S.C.I. IF: 14.3. Subject Category: 23/333=6.9% in Oncology, JCR 2025) (First author) 
  43. Y-F Lin, Y-H Lee, Y-H Hsu, Y-J Chen, Y-F Lin, F-Y Cheng and H-W Chiu*. Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease. Nanomedicine 12(22):2741-2756 (2017). (S.C.I. IF: 4.6. Subject Category: 54/180=30.0% in Biotechnology & Applied Microbiology, JCR 2025) (Corresponding author) 
  44. Y-H Hsu, Y-F Lin, C-H Chen, Y-J Chiu and H-W Chiu*. Far-infrared promotes wound healing through activation of Notch1 signaling. Journal of Molecular Medicine 95:1203-1213 (2017). (S.C.I. IF: 5.0. Subject Category: 36/192=18.8% in Genetics & Heredity, JCR 2025) (Corresponding author) 
  45. Y-H Wu, C-W Hong, Y-C Wang, W-J Huang, Y-L Yeh, B-J Wang, Y-J Wang* and H-W Chiu*. A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer. Cancer letters 400:79-88 (2017). (S.C.I. IF: 11.8. Subject Category: 29/333=8.7% in Oncology, JCR 2025). (Corresponding author)
  46. H-W Chiu, C-H Chen, Y-J Chen and Y-H Hsu. Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. PLoS ONE. 12(3): e0174042 (2017). (S.C.I. IF: 2.8. Subject Category: 48/140 =34.3% in Multidisciplinary Sciences, JCR 2025). (First author) 
  47. H-W Chiu, C-H Chen, J-N Chang, C-H Chen and Y-H Hsu. Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy. Journal of Molecular Medicine. 94(7): 809-819 (2016). (S.C.I. IF: 5.0. Subject Category: 36/192=18.8% in Genetics & Heredity, JCR 2025) (First author) 
  48. H-W Chiu, Y-L Yeh, Y-C Wang, W-J Huang, S-Y Ho, P Lin and Y-J Wang. Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model. Molecular Cancer 15(1):46 (2016). (S.C.I. IF: 42.2. Subject Category: 4/328=1.2% in Biochemistry & Molecular Biology, JCR 2025) (First author) 
  49. H-W Chiu, S-W Lin, L-C Lin, Y-H Hsu, Y-F Lin, S-Y Ho, Y-H Wu, and Y-J Wang. Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6. Cancer letters 365:229-239 (2015). (S.C.I. IF: 11.8. Subject Category: 29/333=8.7% in Oncology, JCR 2025) (First author)
  50. H-W Chiu, T Xia, Y-H Lee, C-W Chen, J-C Tsai, and Y-J Wang. Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress. Nanoscale 7: 736-746 (2015). (S.C.I. IF: 5.2. Subject Category: 46/191=24.1% in Physics, Applied, JCR 2025) (First author)
  51. H-W Chiu, Y-C Tseng, Y-H Hsu, Y-F Lin, N-P Foo, H-R Guo and Y-J Wang. Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of ubiquitin-proteasome system in human sarcoma cells. Cancer letters 356: 762-772 (2015). (S.C.I. IF: 11.8. Subject Category: 29/333=8.7% in Oncology, JCR 2025) (First author)
  52. Y-H Lee, F-Y Cheng, H-W Chiu, J-C Tsai, C-Y Fang, C-W Chen and Y-J Wang. Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts. Biomaterials 35:4706-4715 (2014). (S.C.I. IF: 13.6. Subject Category: 8/130=6.2% in Engineering, Biomedical, JCR 2025) 
  53. H-W Chiu, M-H Chen, W-H Fang, C-M Huang, Y-L Chen, M-D Wu, G-F Yuan, M-J Wu and Y-J Wang. Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia and prostate cancer. Journal of Agricultural and Food Chemistry 61:4379-86 (2013). (S.C.I. IF: 6.7. Subject Category: 12/95=12.6% in Agriculture, multidisciplinary, JCR 2025) (First author)
  54. H-W Chiu, Y-S Ho and Y-J Wang. Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through down-regulation of survivin. Journal of Molecular Medicine. 89:927-941 (2011). (S.C.I. IF: 5.0. Subject Category: 36/192=18.8% in Genetics & Heredity, JCR 2025) (First author) 
  55. H-W Chiu, J-H Lin, Y-A Chen, S-Y Ho and Y-J Wang. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy. 6: 353-365 (2010). (S.C.I. IF: 18.6. Subject Category: 13/207=6.3% in Cell Biology, JCR 2025) (First author) 
  56. H-W Chiu, S-Y Ho, H-R Guo and Y-J Wang. Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. Autophagy. 5:472-483 (2009). (S.C.I. IF: 18.6. Subject Category: 13/207=6.3% in Cell Biology, JCR 2025) (First author) 

Conference Paper

  1. Invited speaker. Hui-Wen Chiu. Microplastics exposure and human health: Current evidence for renal and hepatic effects. 57th Asia-Pacific Academic Consortium for Public Health Conference. Tainan, Taiwan, Oct. 20-23, 2026.
  2. Invited speaker. Hui-Wen Chiu. Kidneys at risk: The hidden impact of particulate plastics. The 40th Joint Annual Conference of Biomedical Sciences第40屆生物醫學聯合學術年會。臺北，台灣。2026年3月21-22日。
  3. Keynote lecture. Hui-Wen Chiu. The health concern of particulate plastics. The 15th National Conference in Toxicology (NCT15). Bangkok, Thailand, Sep. 3-4, 2025.
  4. Hung-Jin Huang, Li-Chin Sung, Yen-Chung Lin, Hui-Wen Chiu. Artificial intelligence-based drug design in development of DDR kinase inhibitors as therapeutic potential for chronic kidney disease. 2025台灣毒物學學會年會暨第12屆海峽兩岸學術研討會。臺北，台灣。2025 年02月07-09 日。 (LC-HRMS)-Based Suspect Screening Analysis” 21st TSMS Annual Conference, Jul. 1-3, 2025.
  5. Wen-Chih Liu, Yu-Jhe Chiu and Hui-Wen Chiu. Understanding the role of matrix metalloproteinase 7 in chronic kidney disease progression. 61st ERA Congress, Stockholm & Virtual, May 23-26, 2024. 
  6. Hung-Jin Huang, Cai-Mei Zheng and Hui-Wen Chiu. The alternative methods to animal experimentation in the identification of non-hazardous drugs for chronic kidney disease by targeting prostaglandin E2 receptor. 10th International Congress of Asian Society of Toxicology, Taipei, Taiwan, July 17-20, 2023.
  7. Ruei-Yu Su, Yu-Hsuan Lee, Yi-Jie Chen and Hui-Wen Chiu. Urban particulate matter induces nephrotoxicity by increasing the CSF2 pathway and extracellular vesicles production. 2023 Asia Pacific Societies for Extracellular Vesicles Conference, Taipei, Taiwan, Mar. 31-Apr. 2, 2023. 
  8. Hui-Wen Chiu, Kuo-Cheng Lu, Yi-Chou Hou, Chien-Lin Lu, Cai-Mei Zheng. Etelcalcetide improves bone turnover in renal osteodystrophy possibly through regulation of bone immunity and inflammation. Annual Meeting of American Society of Nephrology. Orlando, FL, with a virtual component. Nov 3-6, 2022. 
  9. Yu-Hsuan Huang, Hui-Wen Chiu and Yu-Hsuan Lee. The role of autophagy regulated-NLRP3 inflammasome inactivation in the therapy of alcoholic liver disease. 9th International Congress of Asian Society of Toxicology (ASIATOX-IX). Hangzhou, Zhejiang Province, China (Online). October 20-23, 2021.
  10. Hui-Wen Chiu, Kuo-Cheng Lu and Cai-Mei Zheng. Salubrinal improves osteoclast differentiation and vascular calcification in uremic millennium through inhibition of endoplasmic reticulum stress condition. 57th ERA-EDTA. Fully virtual. June 6-9, 2020.
  11. Hui-Wen Chiu, Kuo-Cheng Lu, Yung-Ho Hsu, Mai-Szu Wu, Jia-Fuh Shyu, Yuh-Feng Lin and Cai-Mei Zheng. Cinacalcet hydrochloride improves bone disorder in chronic kidney disease by regulating osteoclast endoplasmic reticulum stress and autophagy. American Society for Bone and Mineral Research (ASBMR) 2019 Annual Meeting. Florida, USA. September 20 -23, 2019.
  12. Yuh-Feng Lin, Yu-Hsuan Lee and Hui-Wen Chiu. Crosstalk between endoplasmic reticulum stress and autophagy in kidney diseases. International Society for Extracellular Vesicles (ISEV) Annual Meeting 2019. Kyoto, Japan, 24-28 April 2019.
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